The examination of an Estonian girl with progressive muscle weakness brought about collaboration of researchers from ten countries, which led to the discovery of a new form of muscular dystrophy caused by changes in the Jagged2 (JAG2) gene. In the research, a special muscle magnetic resonance imaging study was used in Estonia for the first time, revealing a pattern of muscle involvement characteristic of pathogenic variants in JAG2.
Dr. Ryan Wilson, a post-doctoral fellow in the School of Nursing, says AF is the most commonly diagnosed arrhythmia (irregular heartbeat) in the world. Despite that, he says many people do not understand the pre-diagnosis symptoms and tend to ignore them. In fact, 77 per cent of the women in his most recent study had experienced symptoms for more than a year before receiving a diagnosis.
A study published in July 2020 hypothesized a link between bradykinin, a well-known peptide, and severe cases of COVID-19. TTUHSC's Vardan Karamyan, Ph.D., found the article intriguing because it discussed bradykinin, one of three specific peptides with which his lab has much experience. In a focused review published in March by Physiological Reports, Karamyan suggests two other bioactive peptides also may be involved in the same processes and mechanisms proposed in the original paper.
Virtual care provided through telephone or videoconference has been broadly implemented in recent months because of the COVID-19 pandemic. A new analysis of published studies has examined the accuracy and reliability of virtual compared with in-person cognitive assessments for diagnosing dementia or mild cognitive impairment.
Investigators found similarities in the bacterial composition of the mouth among patients with early rheumatoid arthritis and those at risk of developing the disease, compared with healthy individuals who were not at risk. The findings come from a study published in Arthritis & Rheumatology.
Researchers from AMBER and Trinity College Dublin have developed next-generation, graphene-based sensing technology using their innovative G-Putty material. The team's printed sensors are 50 times more sensitive than the industry standard and outperform other comparable nano-enabled sensors in an important metric seen as a game-changer in the industry: flexibility.
For patients with brain metastases, amino acid positron emission tomography (PET) can provide valuable information about the effectiveness of state-of-the-art treatments. When treatment monitoring with contrast-enhanced magnetic resonance imaging (MRI) is unclear, adding 18F-FET PET can help to accurately diagnose recurring brain metastases and reliably assess patient response. This research was published in The Journal of Nuclear Medicine.
In Frontiers in Immunology, pathologists outline how the immunome -- all of the genes collectively expressed by an individual's immune cells -- holds the potential to provide researchers and physicians with unprecedented insight into an individual's health.
Over the years, physicians and historians have attributed Shackleton's failing health during his Antarctic expeditions to scurvy or a congenital heart defect. By studying other explorers and learning they had symptoms comparable to those of Shackleton, researchers concluded that beriberi provided a sound scientific and medical explanation for the famed explorer's health struggles.
In a study proving feasibility, researchers at Duke Health showed that their testing technology can accurately distinguish between a viral and a bacterial infection for respiratory illness - a critical difference that determines whether antibiotics are warranted. And, importantly, the test provided results in under an hour.