Humans are exposed to a variety of toxins and chemicals every day. According to the epithelial barrier hypothesis, exposure to many of these substances damages the epithelium, the thin layer of cells that covers the surface of our skin, lungs and intestine. Defective epithelial barriers have been linked to a rise in almost two billion allergic, autoimmune, neurodegenerative and psychiatric diseases.
To make drugs and their development safer for children, researchers at Aalto University and the pharmaceutical company Novartis have developed a method that could help determine safe drug doses more quickly. In their study, the team created a model of how organs develop that is more data-driven and consequently less prone to bias.
To understand the effect of sleep seizures, UVA Health researchers monitored the brain and heart activity of people with epilepsy as they slept.
What The Study Did: This study describes an association between the Pfizer-BioNTech BNT162b2 vaccine and decreased risk of symptomatic and asymptomatic infections with SARS-CoV-2 in hospital employees.
What The Study Did: This study estimates the association between Pfizer-BioNTech BNT162b2 vaccination and symptomatic and asymptomatic SARS-CoV-2 infections among health care workers more than seven days after getting a second vaccine dose.
A team of researchers from UCLA, Cedars-Sinai and the Cystic Fibrosis Foundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis. The findings could help scientists in their search for specific cell types that represent prime targets for genetic and cell therapies for cystic fibrosis.
What The Study Did: Researchers compared health care use among patients with COVID-19 who were enrolled in a home monitoring program with similar patients who were not enrolled.
Last year, researchers used a mouse model that included immune-reactive T cells from patients with Crohn's disease in a proof-of-principle demonstration that a flagellin-directed immunotherapy might provide similar benefits in patients. Now they have moved a step closer to possible clinical testing of this treatment, with a study, published in the journal Gastroenterology, that is the first to describe IgG antibodies in Crohn's disease specific for human-derived flagellins of bacteria in the Lachnospiraceae family.
In an article published in PLOS ONE, scientists at a FAPESP-supported research center describe the impact of hypoproteinemia on the expression of microRNAs associated with kidney development in rat embryos.
Experts at Cincinnati Children's and Stanford screened a library of 4500 compounds to find one, called AG1296, that shows promise as a potential treatment for the rare lung disease PAH.