Researchers from Indiana University have identified key genetic changes in the interstitial kidney tissue of people with diabetes, a discovery that signifies the potential for a revolutionary new genetic approach to the treatment of kidney disease. They will contribute their findings to the Kidney Precision Medicine Project's (KPMP) "cell atlas," a set of maps used to classify and locate different cell types and structures within the kidney.
Children born as a result of fertility treatment have different growth patterns to naturally-conceived children but, by the time they reach the age of 17, they are of similar height, weight and body mass index (BMI), according to research published in Human Reproduction.
The observational study examined associations between maternal cardiovascular health during pregnancy (as measured by body mass index, blood pressure, total cholesterol level, glucose level and smoking) with the later cardiovascular health of their offspring at ages 10 to 14 years old (as measured by body mass index, blood pressure, total cholesterol level and glucose level).
In a recent study, published in The Journal of Clinical Investigation, University Hospitals (UH) Cleveland Medical Center and Case Western Reserve University School of Medicine researchers have found that skeletal muscle significantly affects how the body stores and metabolizes fat.
Antipsychotic drugs not only block dopamine signaling in the brain but also in the pancreas, leading to uncontrolled production of blood glucose-regulating hormones, obesity and diabetes.
A technology that is widely used by commercial genetic testing companies is 'extremely unreliable' in detecting very rare variants, meaning results suggesting individuals carry rare disease-causing genetic variants are usually wrong, according to new research published in the BMJ.
Knowledge on how cells communicate is an important key to understanding many biological systems and diseases. A research team led by researchers at the University of Gothenburg has now used a unique combination of methods to map the mechanism behind cellular communication. Their findings can potentially improve understanding of the underlying mechanism behind type 2 diabetes.
Monash University researchers have uncovered the barrier to β-cell (beta cell) regeneration that could pave the way for improved treatments for diabetes and diseases that involve organ and tissue damage.
COVID-19 vaccine prioritization should prioritize those with advanced cardiovascular (CVD) disease over well-managed CVD disease, according to an American College of Cardiology (ACC) health policy statement published in the Journal of the American College of Cardiology (JACC).
A new genetic study of Native Hawaiians by Charleston Chiang at the University of Southern California and colleagues finds that people who have a greater proportion of Polynesian ancestry in their genomes face a higher risk of obesity, Type-2 diabetes and heart failure. The study is published February 11 in PLOS Genetics.