Researchers have finally cracked the code of a bewildering pediatric disease that sets off a characteristic cytokine storm--a harmful immune system overaction resembling one that arises in COVID-19 cases--and can lead to catastrophic multisystem organ failure or neurodegeneration. Their study, which identifies the cause of the cytokine storm and possible treatments, was published in Nature Medicine in May.
In an article published in PLOS ONE, scientists at a FAPESP-supported research center describe the impact of hypoproteinemia on the expression of microRNAs associated with kidney development in rat embryos.
Subtle differences in the shape of the brain that are present in adolescence are associated with the development of psychosis, according to an international team. The "sobering" results were made using the largest study to date of brain scans in adolescents at risk for psychosis.
Researchers at the Medical University of South Carolina (MUSC) report in Neuropsychopharmacology that a mutation in the gene EPHB2 is linked to increased autism risk in girls.
There is currently no consensus on what quality end-of-life care for children with cancer looks like, or how to measure and deliver it; however, investigators recently assembled an expert panel to help fill this void. In a study published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the panel endorsed 16 measures that cover different aspects of care that are important for children with cancer and their families.
Experts at Cincinnati Children's and Stanford screened a library of 4500 compounds to find one, called AG1296, that shows promise as a potential treatment for the rare lung disease PAH.
Using whole exome sequencing, CHOP researchers discovered a genetic mutation responsible for a new condition that prevents patients from making B cells and antibodies to fight infections. The study describing this condition, which CHOP researchers named PU.1 Mutated agammaglobulinemia (PU.MA), was published today in the Journal of Experimental Medicine.
The recommendations come from an international team, led by McMaster University. The international guideline panel included 22 health-care professionals, school administrators, and parents of children with and without food allergy, along with a team of six researchers with methodology expertise. A systematic literature review of practices for managing food allergy in schools found a lack of high-quality evidence, so the guideline recommendations are graded as conditional.
The latest evidence for epigenetic mechanisms associated with transgenerational disease and public policy implications
A new USC study suggests that certain neighborhoods - particularly those characterized by poverty and unemployment - may pose an environmental risk to the developing brains of children, impacting neurocognitive performance and even brain size.