Researchers in Japan have compiled a first-of-its-kind genetic database for autoimmune and autoinflammatory diseases. This resource will allow experts to more deeply understand how immune disorders develop and plan future drug discovery projects. Scientists also hope this atlas of immune-related genome data may eventually be applied to investigations of infectious diseases like COVID-19.
The international consortium today announces a series of publications in a special collection of Nature that resulted from the first phase of the Vertebrate Genome Project (VGP) to release 16 high quality reference genomes. The research group led by Professor Guojie Zhang of the Department of Biology has made substantial contributions to the VGP and this first wave of publications.
Oxytocin and arginine vasopressin are two hormones in the endocrine system that can act as neurotransmitters and regulate -in vertebrates and invertebrates- a wide range of biological functions, such as bonding formation, breastfeeding, birth or arterial pressure. Biochemists in the pregenomic era, named these genes differently in different species, due to small protein coding differences.
A bold project to read the complete genetic sequences of every known vertebrate species reaches its first milestone by publishing new methods and the first 25 high-quality genomes.
A team of the University of Michigan (U-M), spearheaded by Nigel Michki, a graduate student, and Assistant Professor Dawen Cai in the departments of Biophysics (LS&A) and Cell and Developmental Biology at the Medical School, identified many genes that are important in fruit flies' neuron development, and that had never been described before in that context.
When combined with drugs currently used to treat hepatitis C, the antiviral remdesivir is 10 times more effective in treating cells infected with SARS-CoV-2, the virus that causes COVID-19.
As part of a collaborative effort with scientists at Columbia University, researchers at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS) have uncovered the atomic structure of SLAC1 using single particle cryo-electron microscopy (cryo-EM).
Brain research and advocacy nonprofit Cohen Veterans Bioscience (CVB) today announced the launch of a National TBI Precision Solutions Research Roadmap, with the advent of the first in a series of publications resulting from its Brain Trauma Blueprint program. The Brain Trauma Blueprint is a framework that enables stakeholder groups across government, academia, foundations, and industry to advance precision diagnostics and treatments for brain trauma through a coordinated effort.
A new way to identify tumours that could be sensitive to particular immunotherapies has been developed using data from thousands of NHS cancer patient samples sequenced through the 100,000 Genomes Project. The MMRDetect clinical algorithm makes it possible to identify tumours that have 'mismatch repair deficiencies' and then improve the personalisation of cancer therapies to exploit those weaknesses.
Hazelnut is widely grown for its rich oleic acid content and flavor. However, owing to the unavailability of high-quality genetic resources for hazelnut, crop improvement has remained a significant challenge. A new study published in Horticulture Research presents a high-quality whole genome analysis of Chinese hazelnut, along with identification of several genes underlying economically important traits like oil content and disease resistance. These findings can lead to improvements in hazelnut yield worldwide.