Researchers have mapped all possible mutations in the amyloid beta peptide and tested how this influences its aggregation into plaques, a pathological hallmark of Alzheimer's disease. The comprehensive mutation map, which is the first of its kind, can help predict whether a mutation can make an individual more prone to developing Alzheimer's disease later in life. It will also help researchers better understand the biological mechanisms that control the onset of the disease.
Each spring in the North Sea, tiny algae grow in large numbers and release loads of sugar into the water - a feast for bacteria. Scientists from the Max Planck Institute for Marine Microbiology and the University of Greifswald have now investigated the order of the bacterial menu: first the easy-to-digest yummy pieces, then the chewy stuff. This insight was only possible by investigating special bacterial proteins that could be key for understanding marine carbon cycling.
Researchers at the Buck Institute analyzed data from the COVID-19 Symptom Tracker app used by 3 million people in the United Kingdom, adding the use of immunosuppressant medication, use of a mobility aid, shortness of breath, fever, and fatigue to the list of symptoms and comorbidities that increase the risk for severe COVID-19. Results are published in the Journal of Medical Internet Research.
Sanger Institute researchers and their collaborators published the full genetic timeline of the bacterium, Enterococcus faecalis showing the influence of human behaviour on the development of different strains.
Researchers identified and characterized rare cell types in the esophagus, stomach and upper part of the small intestine, using single cell RNA sequencing. They provide detailed gene expression analyses for all epithelial cells in these organs. Furthermore, they identified a rare cell type that is most likely responsible for the secretion of high volumes of water in humans, providing a link to gastrointestinal defects in patients with cystic fibrosis.
China is the origin of one of the world's biggest fruit crops: the domesticated peach. Researchers have conducted studies on peach's wild relatives and local domesticated varieties in China to identify genes responsible for the plant's adaptation to multiple environmental factors. The findings provide detailed genetic insights that could help plant breeders improve the peach trees' resilience to stresses caused by climate change.
Researchers at the UAB have designed minimalist biostructures that imitate natural enzymes, capable of carrying out two differentiated and reversibly regulated activities thanks to a unique combination of structural and functional properties. The strategy used opens the door to the creation of "intelligent" nanomaterials with tailor-made combinations of catalytic functions.
Malaria is the deadliest pathogen in human history, and by studying the strains of malaria that birds carry, scientists might be able to help prevent the disease in humans. Researchers analyzed blood samples of more than 1,000 species of birds from the Andes looking for malaria; they found that the strains of malaria present in a local area don't always neatly align with the types of birds living there.
The University of Queensland has developed a sophisticated plant genomic model, as part of a project to help conserve the critically endangered Macadamia jansenii. Discovered in 1982 by a Central Queensland farmer Ray Jansen, there are only Macadamia jansenii 100 trees in existence. The Australian bushfires nearly wiped out the entire population in 2019. Genomic mapping of the species will help in conservation efforts.
A team of scientists from Geisinger and Tempus have found that artificial intelligence can predict risk of new atrial fibrillation (AF) and AF-related stroke.