Combining expertise has shed new light on how cells self-destruct during microbial infection.
Deep down in the seafloor anaerobic microbes consume large amounts of methane, a potent greenhouse gas. Even though this process is a crucial element of the global carbon cycle, it is still poorly understood. Scientists from Bremen and Israel now found the solution to a long-standing enigma in this process: why methane carbon isotopes behave so differently than expected. In a joint effort with their colleagues they present the answer in the journal Science Advances.
Stem cells have the ability to turn into different types of cell. Now, in research published in Cell Stem Cell and funded by the Medical Research Council, scientists at the University of Exeter's Living Systems Institute, working with colleagues from the University of Cambridge, have developed a method to organise lab-grown stem cells into an accurate model of the first stage of human embryo development.
A new study, published in JCI insight, looks at how Brd4, a regulator of the innate immune response, influences diet-induced obesity. The researchers believe that Brd4 could be used as a target for obesity and insulin resistance.
Researchers at the Federal University of Rio de Janeiro (UFRJ), in Brazil, have found a crucial link between phase transition (aggregation) of mutant p53 protein and cancer pathology. The study opens new paths for the development of novels drugs against the disease. The results have been published in advance in the scientific journal Chemical Science.
T-cell acute lymphoblastic leukemia is an aggressive cancer type that mostly affects children. The standard treatment is chemotherapy, but about one in four patients do not respond or develop resistance to this. Now, researchers from the University of Copenhagen have found a combination treatment that could benefit these patients and increase the survival rate.
Small changes in the structure of DNA have been implicated in breast cancer and other diseases, but they've been extremely difficult to detect -- until now. Using what they describe as a "chemical nose," UC Riverside chemists are able to "smell" when bits of DNA are folded in unusual ways.
Steven Poelzing, associate professor at the Fralin Biomedical Research Institute at VTC, led a team of cardiovascular scientists studying electrical conduction in the heart, showing increased sodium and calcium levels in the bloodstream helps keep dangerous heart rhythms at bay.
The Sumatran rhinoceros (Dicerorhinus sumatrensis) is critically endangered, with fewer than 100 individuals surviving in Indonesia on the islands of Sumatra and Borneo. To ensure survival of the threatened species, accurate censusing is necessary to determine the genetic diversity of remaining populations for conservation and management plans. A new study characterized 29 novel polymorphic microsatellite markers -- repetitive DNA sequences -- that serve as a reliable censusing method for wild Sumatran rhinos.
University of New Mexico Researchers Create Open Source Computational Tool to Rapidly Screen Molecules For COVID-Fighting Properties.