One of the characteristic hallmarks of Alzheimer's disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they've largely failed in clinical trials. New research by Salk scientists upends conventional views of the origin of one prevalent type of plaque, indicating a reason why treatments have been unsuccessful.
The ability to grow the cells of one species within an organism of a different species offers scientists a powerful tool for research and medicine. It's an approach that could advance our understanding of early human development, disease progression and aging, and also holds promise for organ transplantation and for testing therapeutics. Salk researchers have now come one step closer toward this goal by demonstrating a new integration of human cells into animal tissue.
Some snake species slither across the ground, while others climb trees, dive through sand or glide across water. Today, scientists report that the surface chemistry of snake scales varies among species that negotiate these different terrains. The findings could have implications for designing durable materials, as well as robots that mimic snake locomotion to cross surfaces that would otherwise be impassable. The researchers will present their results at ACS Spring 2021.
To better understand how RNA in bacteria gives rise to protein--and potentially target these processes in the design of new antibiotics--researchers are turning their attention to the unique way this process happens in bacteria. University of Michigan researchers have directly observed previously hidden RNA regulatory mechanisms within bacteria. The results are published in PNAS.
Bird genomes contain surprisingly few tRNA genes, suggesting that they have evolved to use their limited tRNA repertoire more efficiently.
Researchers from Tokyo Medical and Dental University (TMDU) have found that certain cells in mouse craniums respond to increased expression of a gene called Dlx5 during early stages of embryonic development. They observed that a layer of these cells formed more bone and cartilage in mice engineered with high Dlx5 levels. Their interesting results provide crucial information for the mechanistic role of this gene in cell fate during cranial development.
A team of UBC Okanagan researchers has determined that the type of fats a mother consumes while breastfeeding can have long-term implications on her infant's gut health.Their study suggests that the type of fat consumed during breastfeeding could differentially impact an infant's intestinal microbial communities, immune development and disease risk.
The heat-shock protein DNAJC9 has a surprising dual histone chaperone functionality a new study in Molecular Cell shows. The protein is the first shown to actively release histones that are trapped in non-specific interactions with DNA, directing them back to their job of organizing chromatin in the cell.
How do cells judge their size and know when to stop dividing? This study provides a new answer by tackling the problem in reverse.
A study led by researchers at IUPUI has found that blow flies may be the answer to monitoring environmental change without disturbing local wildlife.