Though neurodegenerative diseases are becoming more common in today's aging societies, the exact way in which accumulated abnormal proteins become toxic to neurons is unknown. In a recent study conducted at Daegu Gyeongbuk Institute of Science and Technology, Korea, scientists have discovered a new mechanism of action by which these abnormal proteins actually unlock the normally latent toxicity of native proteins. Their results represent a completely new avenue toward the development of effective therapies.
Researchers have identified a gene responsible for the spread of triple-negative breast cancer to other parts of the body and developed a potential way to stop it.
NRL researchers led a team of scientists who discovered some of the youngest known radio jets launched by growing supermassive black holes.
A new synthetic probe offers a safe and straightforward approach for visualizing chromosome tips in living cells. The probe was designed by scientists at the Institute for Integrated Cell-Material Science (iCeMS) and colleagues at Kyoto University, and could advance research into aging and a wide range of diseases, including cancers. The details were published in the Journal of the American Chemical Society.
Researchers at the University of Tokyo have identified how the architecture of the cell nucleus can change gene activity in plants. This discovery reveals fundamental knowledge about genome regulation and points towards future methods for potentially manipulating the expression of many genes simultaneously.
Multilayer plastic materials are ubiquitous in food and medical supply packaging, particularly since layering polymers can give those films specific properties, like heat resistance or oxygen and moisture control. But despite their utility, those ever-present plastics are impossible to recycle using conventional methods.
For more than a decade, TTUHSC's Hiranmoy Das, Ph.D., has been investigating how KLF2 influences the development of bone and musculoskeletal diseases. Most recently, Das attempted to determine if inducing KLF2 levels in dental pulp derived stem cells will promote osteoblast and the building of new bone. His study, "KLF2 regulates dental pulp-derived stem cell differentiation through the induction of mitophagy and altering mitochondrial metabolism," was published in the September issue of Redox Biology.
Researchers from the University of Plymouth's International Marine Litter Research Unit have identified the highest recorded microplastics ever found on Earth - at an altitude of more than 8,000 metres, close to the summit of Mount Everest.