In this latest press release from the Imperial Brands Science website, we detail how our researchers developed an advanced 3D lung tissue model, leading to the first peer-reviewed vaping study evaluating repeated cigarette smoke and aerosol exposure. Results showed minimal effects to lung tissue from vape aerosol compared to cigarette smoke.
Experts at Cincinnati Children's and Stanford screened a library of 4500 compounds to find one, called AG1296, that shows promise as a potential treatment for the rare lung disease PAH.
Scientists from Russia and Italy studied a new axis of the pathway that prevents the development of liver fibrosis. The role of GILZ protein in curbing the disease progression was shown in a study using mice models and confirmed by clinical data. These findings can be used in the treatment of liver fibrosis in humans.
Deep down in the seafloor anaerobic microbes consume large amounts of methane, a potent greenhouse gas. Even though this process is a crucial element of the global carbon cycle, it is still poorly understood. Scientists from Bremen and Israel now found the solution to a long-standing enigma in this process: why methane carbon isotopes behave so differently than expected. In a joint effort with their colleagues they present the answer in the journal Science Advances.
A protein called Sir2 may facilitate C. albicans' transition from ovoid yeast to thread-like hypha. C. albicans cells that were missing the Sir2 gene were less likely to form true hyphae in lab experiments than cells of the same species that had that gene.
With the help of their custom-built super-resolution microscope, EPFL biophysicists have discovered where and why mitochondria divide, putting to rest controversy about the underlying molecular machinery of mitochondrial fission. Mitochondria either split in half or cut off their ends to self-regulate. The results are published in Nature.
A group of researchers at the Hong Kong University of Science and Technology (HKUST) has uncovered the mechanism of how DNA is being melted to start bacterial gene transcription and how one class of antibiotics inhibits this process - an important way in killing bacteria. This discovery provides useful insight on the development of new antibiotics for bacteria that is antimicrobial resistance.
A new study, published in JCI insight, looks at how Brd4, a regulator of the innate immune response, influences diet-induced obesity. The researchers believe that Brd4 could be used as a target for obesity and insulin resistance.
Researchers at the Federal University of Rio de Janeiro (UFRJ), in Brazil, have found a crucial link between phase transition (aggregation) of mutant p53 protein and cancer pathology. The study opens new paths for the development of novels drugs against the disease. The results have been published in advance in the scientific journal Chemical Science.
Small changes in the structure of DNA have been implicated in breast cancer and other diseases, but they've been extremely difficult to detect -- until now. Using what they describe as a "chemical nose," UC Riverside chemists are able to "smell" when bits of DNA are folded in unusual ways.