Researchers from Rochester Regional Health used graded doses to successfully administer a second dose of the Moderna vaccine to two patients who had an immediate hypersensitivity reaction with the first dose. Their case report is published today in Annals of Internal Medicine.
USC study forecasts disease-modifying treatments for Alzheimer's disease would help Medicaid avoid paying $186 billion from 2021-2040.
The American College of Physicians (ACP) has issued Best Practice Advice suggesting that a shorter course of antibiotics may be appropriate for some common bacterial infections, as overuse, resistance, and long and unnecessary use remain major health care issues. The paper addresses best practices for prescribing appropriate and short-duration antibiotics for patients presenting with these infections. ACP's Best Practice Advice is published in Annals of Internal Medicine.
A team of researchers has identified several candidates for drugs against the coronavirus SARS-CoV-2 at DESY´s high-brilliance X-ray lightsource PETRA III. They bind to an important protein of the virus and could thus be the basis for a drug against Covid-19. In a massive X-ray screening, the researchers tested almost 6000 known active substances that already exist for the treatment of other diseases, and report the results now online in the journal Science.
Researchers have discovered and are developing a non-invasive biomarker that can be used to measure and track performance of senolytics: a class of drugs that selectively eliminate senescent cells. The discovery is expected to further efforts to develop treatments for a myriad of chronic age-related conditions. This biomarker is a unique signaling lipid which is released when senescent cells are forced to die. The metabolite is detectible in blood and urine, making non-invasive testing possible.
The April edition of SLAS Technology features the cover article "Therapeutic Potential of Reactive Oxygen Species: State of the Art and Recent Advances" by Valeria Graceffa, Ph.D. (Institute of Technology Sligo, Sligo, Ireland).
Children and young adults who receive CAR T-cell therapy for the most common childhood cancer - acute lymphoblastic leukemia - suffer remarkably fewer relapses and are far more likely to survive when the treatment is paired with a subsequent stem cell transplant, a new study finds.
This study explores the impact of alcohol on epigenetics, a term that defines chemical modifications of DNA (without changing its nucleotide sequence), proteins and mRNA (messenger RNA), and the action of regulatory non-coding RNAs. Epigenetic changes affect the adequate functioning of cellular events such as protein synthesis, protein trafficking, metabolic control, or energy production. Besides, the study examines new chemical agents that may interfere with ethanol's action on epigenetic targets.
A phase 3 clinical trial finds an anti-inflammatory drug used in rheumatoid arthritis can preserve lung function in patients with systemic sclerosis.
A review of more than 10,000 medical records in urban Malawi, South Africa, Uganda and Zimbabwe has yielded important insight about pregnancy and neonatal outcomes in these communities as well as the frequency with which different complications occur. The data provide researchers conducting the DELIVER study a frame of reference for assessing the safety of daily PrEP and the monthly dapivirine ring in pregnant women but should be of value to local authorities as well.