The neutron reflexometry method has given scientists an atomic-level insight into the behaviour of Bcl-2, a protein that promotes cancerous cell growth. The new study was carried out by Umeå chemists in collaboration with the research facilities ESS and ISIS and is published in Nature Communications Biology.
A new study found that non-pungent synthetic analog of capsaicin -- the compound that makes chili peppers hot -- made small cell lung cancer cells more responsive to treatment. Small cell lung cancer is a very aggressive form of cancer with a low survival rate.
Researchers have found that DNP peptide, a small intestine-permeable cyclic peptide originally used as an insulin additive to improve absorption into the small intestinal, lowers blood glucose levels in mice. They also found that insulin can be administered orally simply by adding D-form DNP peptide (D-DNP) peptide to injectable insulin used in clinical practice. This study is expected to provide a basis for the development of oral insulin using DNP peptides.
Scientists have made a promising step towards developing a new drug for treating acute myeloid leukaemia, a rare blood disorder.
A study in cells and mice finds a opioid-receptor modifying compound works to relieve pain using the body's own pain-killers, with fewer side effects than opioids.
An international team led by a Skoltech researcher has developed a method of fabrication for biodegradable polymer microcapsules, made more efficient by turning to an unusual source of inspiration - traditional Russian dumpling, or pelmeni, making.
Nagoya University researchers and colleagues have uncovered a molecular pathway that enhances chemotherapy resistance in some pancreatic cancer patients. Targeting an RNA to interrupt its activity could improve patient response to therapy and increase their overall survival.
Optimizing manufacturing of rare precursors to drugs has implications in making medications more globally accessible, affordable Microbial production of drug precursors makes product cycle more sustainable Eliminating need for yew trees that take 80 years to grow makes development of taxol, an anti-cancer drug ingredient, possible for more companies
Hongbo Pang from the U of M College of Pharmacy found a better drug delivery system to treat prostate cancer and bone growth.
Aziridine structures are an important component of several medicines and pharmaceutical drugs, due to which reactions yielding desirable aziridine structures with high purity have received much interest. In a new study, scientists from Japan have reported a high yield of aziridines with high purity from oxazolones using a novel catalyst and look into the underlying mechanism, paving the way for future development of novel drugs and medicines.