Having new COVID-19 vaccines will mean little if people around the world are unable to get vaccinated in a timely manner. Vaccines have to be affordable and available to all countries, and governments must have the administrative and political capacities to deliver them locally to ensure an effective global immunisation strategy against COVID-19, say the authors of a Health Policy piece published in The Lancet.
Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defences: these become, thus, the tumor-associated macrophages (TAMs).
Research from the University of Kent, Goethe-University in Frankfurt am Main, and the Philipps-University in Marburg has provided crucial insights into the biological composition of SARS-CoV-2, the cause of COVID-19, revealing vital clues for the discovery of antiviral drugs.
An antibody loaded onto a porous metal organic framework is released by the acidic environment that surrounds tumors, avoiding the adverse effects of administering the antibody alone.
Dimerization of the human neuropeptides oxytocin and vasopressin can produce new types of bioactive molecules. Such new constructs provide several opportunities to optimize the efficacy of these neuropeptides for therapeutic application. The researchers were inspired for this approach from naturally occurring dimers.
Nagoya University scientists have developed a chemical reaction that produces high yields of a compound used in a wide variety of industries, without needing high temperatures or toxic catalysts. The approach offers a practical and sustainable solution for industrial (meth)acrylate (= acrylate or methacrylate) ester synthesis.
Orally administrating probiotics is ineffective due to the poor inhabitation of exogenous bacteria in host intestines. Chinese scientists report that smectite, a type of mineral clay and classical anti-diarrhoea drug, can promote the expansion of probiotics in the murine gut that subsequently elicits anti-tumor immune responses. Their findings suggest a novel approach to specifically enrich probiotics in the body, with high translational potential for cancer immunotherapy.
When modified using a process known as epoxidation, two naturally occurring lipids are converted into potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways that promote pain and inflammation, researchers report. These modified compounds, called epo-NA5HT and epo-NADA, have much more powerful effects than the molecules from which they are derived, which also regulate pain and inflammation.
Rice University scientists introduce a new catalyst to reduce oxygen to widely used hydrogen peroxide. The process sidesteps complex and expensive processes that generate toxic organic byproducts and large amounts of wastewater.
Chiral N,N-acetals are an important component of several bioactive drugs and medicines. Owing to this, chemical reactions that lead to high-purity yield of the desired 'enantiomeric' form are highly sought after. In a new study, scientists from Japan demonstrate high selectivity formation of N,N-acetals from reactions between 2-aminobenzamide and various diketones in presence of bis(imidazoline)-phosphoric acid catalyst and look into the possible mechanism, opening doors to facile synthesis of novel pharmaceutical drugs.