A new study has shown that underweight and overweight women are at a significantly higher risk of experiencing recurrent miscarriages compared to those of average weight.
Vitamin D deficiency may impair muscle function due to a reduction in energy production in the muscles, according to a mouse study published in the Journal of Endocrinology. Vitamin D deficient mice were found to have impaired muscle mitochondrial function, which may have implications for muscle function, performance and recovery. This may suggest that preventing vitamin D deficiency in older adults could help maintain better muscle strength and function and reduce age related muscle deterioration, but further studies are needed to confirm this.
This new Calcified Tissue International special issue includes a comprehensive series of state-of-the-art reviews on key issues in chronic kidney disease and mineral & bone disorders (CKD-MBD). Authored by leading international experts, the reviews aim to improve understanding and interdisciplinary knowledge of CKD -MBD research and clinical management.
Despite all the advances in medicine, some basic questions remain. For example, people cannot be told with any certainty how long they'll live. Nor can it be predicted exactly when a woman's childbearing years will end. However, a new study offers insights into factors that might predict a woman's age at natural menopause. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).
A new source of energy expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity.
Good cholesterol, which is transported in HDLs (high-density lipoproteins), plays a key part in the prevention of atherosclerosis and thus the risk of cardiovascular disease. However, according to a new paper co-authored by researchers at Karolinska Institutet in Sweden and published in the journal Circulation, the anti-inflammatory properties of HDLs could be an even better biomarker for future cardiovascular events.
Researchers at Osaka University have shown that SLPI, a secretory leukocyte protease inhibitor, coordinates the mutually contradictory actions of parathyroid hormone (PTH) on bone. They revealed the genetic mechanisms and molecular pathways whereby SLPI promotes osteoblast activity to augment bone mass and showed how osteoblasts interact with osteoclasts to subdue bone resorption. This knowledge will inform clinical usage of anabolic PTH in osteoporosis as well as promote development of innovative drugs.
Obesity is linked to heavier periods and may be caused by delayed repair of the womb lining, according to a study published in the Journal of Endocrinology. Using a combined approach, assessing both women and mice, the study suggests an association between higher body weight and greater menstrual blood loss that may result from increased inflammation in the womb lining, delaying its repair.
A new study in mice describes novel neurocircuitry between midbrain structures that control feeding behaviors that are under modulatory control by leptin, a hormone made by body fat. Since the discovery of leptin in the 1990s, researchers have wondered how leptin can suppress appetite.
Exposure to phthalates, a class of chemicals widely used in packaging and consumer products, is known to interfere with normal hormone function and development. Now researchers have found evidence linking pregnant women's exposure to phthalates to altered cognitive outcomes in their infants.