Vitamin D deficiency may impair muscle function due to a reduction in energy production in the muscles, according to a mouse study published in the Journal of Endocrinology. Vitamin D deficient mice were found to have impaired muscle mitochondrial function, which may have implications for muscle function, performance and recovery. This may suggest that preventing vitamin D deficiency in older adults could help maintain better muscle strength and function and reduce age related muscle deterioration, but further studies are needed to confirm this.
* A new method has been developed to measure how fast amyloid fibrils grow. * The team fired a beam of neutrons at the growing fibrils then used a 'contrast matching' method that made most of each fibril invisible to neutrons, so they could analyse the signal from the growing end alone. * The method will help scientists better understand diseases associated with amyloid fibrils, such as Alzheimer's, Parkinson's and Type 2 diabetes.
Scientists at BIH have investigated together with an international team of researchers, how endothelial cells maintain their stable resting state.
Researchers in Japan have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. Metformin's mechanism is different from existing therapeutics which only treat symptoms, such as the blood pressure drug losartan, so researchers believe that a combination these medications at low dose will be highly beneficial.
Patients who are overweight or obese have more severe COVID-19 and are highly likely to require invasive respiratory support, according to a new international study.
It has long been known that obesity is an inflammatory disease. Based on this knowledge, a group of researchers led by Nabil Djouder at the Spanish National Cancer Research Centre (CNIO), decided to try to fight obesity by preventing inflammation. The research, published this week in Nature Metabolism, shows that digoxin, a drug already in use against heart diseases, reduces inflammation and leads to a 40% weight loss in obese mice, without any side effects.
The slurred speech, poor coordination, and sedative effects of drinking too much alcohol may actually be caused by the breakdown of alcohol products produced in the brain, not in the liver as scientists currently think.
Phenformin, in combination with immunotherapies like PD-1 immune checkpoint inhibitors, shows greater promise than phenformin or metformin alone. A clinical trial is under way at MGH to evaluate the use of phenformin with an inhibitor of the BRAF-mutated gene, present in roughly half of all melanomas.
Chronic inflammation is increasingly a focus of research. A recent study has now identified differences in indicators of inflammation between novel diabetes subgroups.
This new Calcified Tissue International special issue includes a comprehensive series of state-of-the-art reviews on key issues in chronic kidney disease and mineral & bone disorders (CKD-MBD). Authored by leading international experts, the reviews aim to improve understanding and interdisciplinary knowledge of CKD -MBD research and clinical management.