COVID-19 patients who are overweight or obese are more likely to develop a more severe infection than patients of healthy weight, and they require oxygen and invasive mechanical ventilation more often. There is no increased risk of death . These conclusions, for which more than 7,000 patients were studied, appear from international research in eleven countries, including the Netherlands (Radboud university medical center).
Researchers in Japan have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. Metformin's mechanism is different from existing therapeutics which only treat symptoms, such as the blood pressure drug losartan, so researchers believe that a combination these medications at low dose will be highly beneficial.
Patients who are overweight or obese have more severe COVID-19 and are highly likely to require invasive respiratory support, according to a new international study.
Phenformin, in combination with immunotherapies like PD-1 immune checkpoint inhibitors, shows greater promise than phenformin or metformin alone. A clinical trial is under way at MGH to evaluate the use of phenformin with an inhibitor of the BRAF-mutated gene, present in roughly half of all melanomas.
Chronic inflammation is increasingly a focus of research. A recent study has now identified differences in indicators of inflammation between novel diabetes subgroups.
Non-alcoholic fatty liver, NAFLD, is associated with several health risks. According to a new registry study led by researchers at Karolinska Institutet in Sweden, NAFLD is linked to a 17-fold increased risk of liver cancer. The findings, published in Hepatology, underscore the need for improved follow-up of NAFLD patients with the goal of reducing the risk of cancer.
UK adults who are overweight or obese retain their weight over time, which is associated with an increased risk of health complications and death, according to a study published in the open access journal BMC Public Health.
A new source of energy expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity.
As demonstrated by multiple studies, women who breastfeed have a lower risk for developing cardiovascular disease and diabetes, though the mechanisms by which these risks are reduced for lactating women are still not fully understood. Duke Appiah, Ph.D., from the Texas Tech University Health Sciences Center and a team of collaborators recently completed a study to see if the presence of excess fat, specifically visceral and pericardial fat, could help explain this finding.
A study by Helmholtz Zentrum München concludes that during the second Corona wave, three to four times more children in Bavaria, Germany were infected with the Corona virus than reported via PCR tests. In addition, the researchers found that about eight times more children had antibodies against SARS-CoV-2 at the end of the second wave in comparison to the end of the first wave. The results are relevant for decision-making on which measures to take to contain the pandemic.