In a new paper published in Nature Communications, Mayo Clinic researchers and collaborators report the protein-coding gene SERPINA5 may worsen tau protein tangles, which are characteristic of Alzheimer's disease, and advance disease. By combining clinical expertise, brain tissue samples, pathology expertise and artificial intelligence, the team clarified and validated the relevance of the gene to Alzheimer's disease.
A new National Academies report on benefits of collaborative care models for dementia cites research and implementation by Regenstrief Institute research scientists. Collaborative care models integrate medical and psychosocial care, delivered by a team of providers.
More than 70% of neurological diseases, including Alzheimer's disease and the concussion-related disorder CTE, are believed to be fueled by protein clusters called tau aggregates. A new study sheds light on how they damage brain cells and could ultimately lead to new therapies for such "tauopathies."
In a new study, researchers from the University of Copenhagen have gained new insights into how signal molecules are transported in some of the longest cells in the nervous system. The discovery is made by examining the transport process in fruit flies. The researchers hope that the results can contribute to understanding human illnesses such as neuropathy and neurodegenerative disease.
A new study suggests that some neurological disorders share a common underlying thread. Staufen1, a protein that accumulates in the brains of patients with certain neurological conditions, is linked to amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, along with other neurological disorders, including Alzheimer's, Parkinson's, and Huntington's disease, according to University of Utah Health scientists.
Engaging in household chores may be beneficial for brain health in older adults. In a recent Baycrest study, older adults who spent more time on household chores showed greater brain size, which is a strong predictor of cognitive health.
Young-onset dementia challenges couples to face a rapidly progressive terminal illness with an uncertain future. By understanding the lived experiences of couples coping with the condition, researchers identified building blocks for a novel couples-based approach to illness management.
One of the characteristic hallmarks of Alzheimer's disease (AD) is the buildup of amyloid-beta plaques in the brain. Most therapies designed to treat AD target these plaques, but they've largely failed in clinical trials. New research by Salk scientists upends conventional views of the origin of one prevalent type of plaque, indicating a reason why treatments have been unsuccessful.
A potential treatment for dementia and epilepsy could look to reduce the amounts of a toxic gas in the brain has been revealed in a new study using rat brain cells.
ABCC1 has been shown in laboratory models to remove a plaque-forming protein known as amyloid beta from specialized endothelial cells that surround and protect the brain and cerebral spinal cord. Building on previous studies, TGen conducted a series of pre-clinical genomic laboratory experiments. Results suggest that ABCC1 not only could export Abeta out of the brain, but that increasing the expression of ABCC1 could reduce Abeta production, thus preventing, or delaying, the onset of Alzheimer's.