The study has demonstrated the involvement of a new Ca2+ ion entry pathway in angiogenesis processes and the formation of new blood vessels. This Ca2+ pathway is known as SOCE (store operated Ca2+ entry).
Hani Kushlaf, MD, an associate professor in both the Department of Neurology and Rehabilitation Medicine and the Department of Pathology and Laboratory Medicine at the University of Cincinnati, is presenting findings on a possible new treatment for Pompe disease virtually at the American Academy of Neurology on April 20.
Recently, researchers have been studying whether shorter variations of HIIT, involving as little as 4-min of high intensity exercise per session (excluding a warm up and cool down), also improve health. A new review paper published in The Journal of Physiology collates a decade's worth of research on the topic of this so-called low-volume high HIIT for health.
It is an old-standing theory in evolutionary ecology: animal species on islands have the tendency to become either giants or dwarfs in comparison to mainland relatives. Since its formulation in the 1960s, however, the 'island rule' has been severely debated by scientists. Researchers solved this debate by analysing thousands of vertebrate species. They show that the island rule effects are widespread in mammals, birds and reptiles, but less evident in amphibians.
Researchers in Japan have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. Metformin's mechanism is different from existing therapeutics which only treat symptoms, such as the blood pressure drug losartan, so researchers believe that a combination these medications at low dose will be highly beneficial.
Previous research has shown a link between the duration of a woman's reproductive life span and her overall metabolic health. By analyzing data from successive surveys spanning the 1959-1962 National Health Examination Survey I through the National Health and Nutrition Examination Survey for 2017-2018, TTUHSC's Duke Appiah, Ph.D., and a group of collaborators investigated factors that may be driving that link for U.S. women, including an increase in age at natural menopause.
Bearded dragon embryos can use two different sets of genes to become a female lizard -- one activated by the sex chromosomes and the other activated by high temperatures during development. Sarah Whiteley and Arthur Georges of the University of Canberra report these new findings April 15th in the journal PLOS Genetics.
Some snake species slither across the ground, while others climb trees, dive through sand or glide across water. Today, scientists report that the surface chemistry of snake scales varies among species that negotiate these different terrains. The findings could have implications for designing durable materials, as well as robots that mimic snake locomotion to cross surfaces that would otherwise be impassable. The researchers will present their results at ACS Spring 2021.
A new study, led by the University of California, Irvine (UCI), reveals how chronic inflammation promotes muscle fibrosis, which could inform the development of new therapies for patients suffering from Duchenne muscular dystrophy (DMD), a fatal muscle disease.
In a randomized controlled study, Penn State researchers found that a Mediterranean diet combined with small portions of lean beef helped lower risk factors for developing heart disease, such as LDL cholesterol.