In a new Yale-led study, researchers find that autism may develop in different regions of the brain in girls than boys and that girls with autism have a larger number of genetic mutations than boys, suggesting that they require a larger "genetic hit" to develop the disorder. The findings appear in the April 16 edition of the journal Brain.
New research sheds light on how autism-spectrum disorder manifests in the brains of girls, prompting the scientists to warn that conclusions drawn from studies conducted primarily in boys should not be assumed to hold true for girls.
A new study has shown that underweight and overweight women are at a significantly higher risk of experiencing recurrent miscarriages compared to those of average weight.
Using mathematical modeling, researchers considered a time very early in evolution when primordial species reproduced using external fertilization. In the model, bigger reproductive cells, or gametes, presented a competitive edge because they could hold more nutrients for a potential zygote. Smaller gametes, however, required fewer resources to make, which put less stress on the parent. Organisms evolved to specialize in large or small gametes, precursors to eggs and sperm.
The list of known genetic mitochondrial disorders is ever-growing, and ongoing research continues to identify new disorders in this category. In an article recently published in Brain, a Japanese-European team of scientists, including researchers from Fujita Health University, describe mutations in the LIG3 gene, which plays a crucial role in mitochondrial DNA replication. These mutations cause a previously unknown syndrome characterized by gut dysmotility, leukoencephalopathy, and neuromuscular abnormalities.
The spatial genome organization is fundamental for the regulation of our genes and has to be established de novo by each individual during early embryogenesis. Max Planck Researchers together with colleagues from the FMI Basel now reveal critical role of the protein HP1a in the 3D genome re-organization after fertilisation. The study published in Nature identifies HP1a as regulator that is involved in establishing the global structure of the genome in the early Drosophila embryo.
Epigenetic regulator HPI1a drives de novo genome reorganization in early Drosophila embryos
Previous research has shown a link between the duration of a woman's reproductive life span and her overall metabolic health. By analyzing data from successive surveys spanning the 1959-1962 National Health Examination Survey I through the National Health and Nutrition Examination Survey for 2017-2018, TTUHSC's Duke Appiah, Ph.D., and a group of collaborators investigated factors that may be driving that link for U.S. women, including an increase in age at natural menopause.
A recent study revealed that to better conserve the giant trevally, an economically important game fish in the Seychelles, its nursery areas should be protected, as well as the bigger areas the large adults of the species frequently use. The study praises the Seychelles Marine Protected Areas and advises that St Joseph Atoll, the nursery area in the study, should not allow extractive fishing for species like giant trevally.
Investigators in China and the United States have injected human stem cells into primate embryos and were able to grow chimeric embryos for a significant period of time--up to 20 days. The research, despite its ethical concerns, has the potential to provide new insights into developmental biology and evolution. It also has implications for developing new models of human biology and disease. The work appears April 15 in the journal Cell.