A new University of South Florida Health (USF Health) study suggests that disruption of chaperone proteins in the aging brain may tip the balance to promote toxic tau accumulation, leading to neurodegenerative diseases like Alzheimer's.
The South-Eastern-Bantu (SEB) language family includes isiZulu, isiXhosa, siSwati, Xitsonga, Tshivenda, Sepedi, Sesotho and Setswana.
EPFL scientists have developed an algorithm that can work out the spatial pattern of gene expression inside the body without the need for microscopes and complicated equipment used currently.
The accumulation of abnormal glycogen in glial cells of the nervous system causes inflammation and degeneration of the brain. This study by IRB Barcelona has been published in the journal Brain.
In a study conducted at the University of Helsinki, researchers found a cause for severe epilepsy resulting in death in Parson Russell Terrier puppies at a few months of age. A change in the PITRM1 gene can lead to a dysfunction of mitochondria, the cellular energy pumps. Concurrently, amyloid-β accumulation and widespread neurodegeneration associated with Alzheimer's disease were identified in the puppies' brains. Changes to the PITRM1 gene in humans also cause a severe but slowly progressing brain disease.
Researchers at Beam Therapeutics have developed a redesigned base editor that shows considerable promise in directly repairing the single-base mutation that causes sickle-cell disease.
A new study led by scientists at VCU Massey Cancer Center suggests that gain-of-function mutations turn p53 into an oncogene, causing cells to replicate uncontrollably and contribute to cancer development. Recently published in Nature Communications, the researchers determined that mutant p53 genes are empowered by a specific protein, PLK3, to copy their genetic code and promote tumor cell proliferation through a process called transactivation.
New basic science research shows what happens to the development of abdominal aortic aneurysms when you inhibit JMJD3 through both genetics and pharmacology.
Intellectual disability is most often caused by changes to the genome that take place in early fetal development and are not found in the parents' DNA. This is why the risk of recurrence in the next sibling of the family is very small, as indicated by a study conducted at the University of Helsinki. Furthermore, Finns do not have a higher risk of inherited developmental disorders compared to other Europeans in spite of the isolated nature of the population.
What keeps some plants squatting close to the soil while others -- even those closely related -- reach high for the skies? New research addressing the architecture and growth habit of plants has provided an answer to this question and may assist in the development of better performing crops.