In a new Yale-led study, researchers find that autism may develop in different regions of the brain in girls than boys and that girls with autism have a larger number of genetic mutations than boys, suggesting that they require a larger "genetic hit" to develop the disorder. The findings appear in the April 16 edition of the journal Brain.
Scientists have figured out how to modify CRISPR's basic architecture to extend its reach beyond the genome and into what's known as the epigenome -- proteins and small molecules that latch onto DNA and control when and where genes are switched on or off.
Scientists at Sanford Burnham Prebys have identified a set of human genes that fight SARS-CoV-2 infection, the virus that causes COVID-19. Knowing which genes help control viral infection can greatly assist researchers' understanding of factors that affect disease severity and also suggest possible therapeutic options. The genes in question are related to interferons, the body's frontline virus fighters.
New research sheds light on how autism-spectrum disorder manifests in the brains of girls, prompting the scientists to warn that conclusions drawn from studies conducted primarily in boys should not be assumed to hold true for girls.
The researchers have discovered that USP7 inhibitors -under development by several pharmaceutical companies for the treatment of cancer- trigger a premature activation of cell cycle proteins, leading to uncontrolled cancer cell division and death. * The paper rejects the premise that the therapeutic efficacy of these inhibitors is due to their effects on activating the tumor suppressor protein P53, as currently accepted by the international scientific community. These results extend the potential use of USP7 inhibitors to a wider range of patients.
In a new study, researchers from the University of Copenhagen have gained new insights into how signal molecules are transported in some of the longest cells in the nervous system. The discovery is made by examining the transport process in fruit flies. The researchers hope that the results can contribute to understanding human illnesses such as neuropathy and neurodegenerative disease.
Oblique Therapeutics AB, a Sweden-based biotech company, in collaboration with Karolinska Institutet (Stockholm, Sweden), Gothenburg University (Sweden) and several local biotechs published promising research results in the highly-acclaimed scientific journal Science Advances (AAAS) entitled: Rational Antibody design for Undruggable Targets using Kinetically Controlled Biomolecular probes.
Scientists have been exploring the cellular mechanisms underlying cancers for centuries in an attempt to successfully treat them. Collating recent research on one avenue of this exploration, the role of cell membrane receptor neuropilin-1, a review article published in Chinese Medical Journal gives a glimpse of how much we know of the disease, how much we still need to find out, and new promising treatments that we've begun to apply.
Novel insights into repair of DNA double-strand breaks (DSB), the most severe form of DNA damage, help scientists understand how proteins work to seal nicks. High resolution images show near-complete cycle of DSB detection and repair. Findings have implications in enhancing cellular response to radiation and chemotherapy.
The list of known genetic mitochondrial disorders is ever-growing, and ongoing research continues to identify new disorders in this category. In an article recently published in Brain, a Japanese-European team of scientists, including researchers from Fujita Health University, describe mutations in the LIG3 gene, which plays a crucial role in mitochondrial DNA replication. These mutations cause a previously unknown syndrome characterized by gut dysmotility, leukoencephalopathy, and neuromuscular abnormalities.