A simple dietary supplement reduces behavioral symptoms in mice with a genetic mutation that causes schizophrenia. After additional experiments, including visualizing the fluorescently stained dancing edge of immature brain cells (video included), researchers concluded that the supplement likely protects proteins that build neurons' cellular skeletons. The supplement, betaine, is already used clinically to treat the unrelated metabolic disease homocystinuria, so experts believe it should be safe to repurpose as a future schizophrenia treatment option.
A COVID-19 vaccine that could provide protection against existing and future strains of the COVID-19 coronavirus, and other coronaviruses, and cost about $1 a dose has shown promising results in early testing.
The objective of this research is to bring to the attention of public health officials, addiction medicine specialists, treatment officials, therapists, and the general public the alarming increase of dangerous toxic adulterants being added to street drugs and their potentially lethal synergistic effects. Also, to provide insights into how these new formulations can have serious pathophysiological effects on individuals with Substance Abuse Disorders (SUDs) during the COVID-19 pandemic.
More than 70% of neurological diseases, including Alzheimer's disease and the concussion-related disorder CTE, are believed to be fueled by protein clusters called tau aggregates. A new study sheds light on how they damage brain cells and could ultimately lead to new therapies for such "tauopathies."
Researchers at Tokyo Medical and Dental University (TMDU) have developed an ingenious therapeutic strategy against chronic myelomonocytic leukemia that links a cytotoxic drug payload to an antibody vector that targets the CD64 marker highly expressed by monocytes and monocytic progenitors. This selective antibody-drug conjugate spares other blood cell lineages thus avoiding the side-effects of conventional anti-cancer drugs such as anemia, infection or bleeding diatheses. Consequently, this drug-delivery tactic shows great promise against other monocyte-related diseases.
Oblique Therapeutics AB, a Sweden-based biotech company, in collaboration with Karolinska Institutet (Stockholm, Sweden), Gothenburg University (Sweden) and several local biotechs published promising research results in the highly-acclaimed scientific journal Science Advances (AAAS) entitled: Rational Antibody design for Undruggable Targets using Kinetically Controlled Biomolecular probes.
Some survivors of ebolavirus outbreaks make antibodies that can broadly neutralize these viruses--and now, scientists at Scripps Research have illuminated how these antibodies can disable the viruses so effectively. The insights may be helpful for developing effective therapies.
Novel insights into repair of DNA double-strand breaks (DSB), the most severe form of DNA damage, help scientists understand how proteins work to seal nicks. High resolution images show near-complete cycle of DSB detection and repair. Findings have implications in enhancing cellular response to radiation and chemotherapy.
Triple-negative breast cancer is an aggressive type of breast cancer with a high fatality rate. Currently, chemotherapy is the major treatment option, but the clinical result is unsatisfactory. A research team led by biologists at City University of Hong Kong (CityU) has identified and characterised a set of specific super-enhancers that stimulate the activity of the related critical cancer genes. The latest findings may help discover new effective drug targets for TNBC patients to improve their survival chance.
A new approach to antibody drug development is helping to optimise these treatments. Researchers at the Department of Biosystems Science and Engineering at ETH Zurich in Basel are using machine learning methods to help them find antibodies that better meet the requirements placed on them, such as ensuring they are better tolerated by the body.