Researchers used platinum and aluminum compounds to create a catalyst which enables certain chemical reactions to occur more efficiently than ever before. The catalyst could significantly reduce energy usage in various industrial and pharmaceutical processes. It also allows for a wider range of sustainable sources to feed the processes, which could reduce the demand for fossil fuels required by them.
A COVID-19 vaccine that could provide protection against existing and future strains of the COVID-19 coronavirus, and other coronaviruses, and cost about $1 a dose has shown promising results in early testing.
The objective of this research is to bring to the attention of public health officials, addiction medicine specialists, treatment officials, therapists, and the general public the alarming increase of dangerous toxic adulterants being added to street drugs and their potentially lethal synergistic effects. Also, to provide insights into how these new formulations can have serious pathophysiological effects on individuals with Substance Abuse Disorders (SUDs) during the COVID-19 pandemic.
More than 70% of neurological diseases, including Alzheimer's disease and the concussion-related disorder CTE, are believed to be fueled by protein clusters called tau aggregates. A new study sheds light on how they damage brain cells and could ultimately lead to new therapies for such "tauopathies."
* A new method has been developed to measure how fast amyloid fibrils grow. * The team fired a beam of neutrons at the growing fibrils then used a 'contrast matching' method that made most of each fibril invisible to neutrons, so they could analyse the signal from the growing end alone. * The method will help scientists better understand diseases associated with amyloid fibrils, such as Alzheimer's, Parkinson's and Type 2 diabetes.
Novel insights into repair of DNA double-strand breaks (DSB), the most severe form of DNA damage, help scientists understand how proteins work to seal nicks. High resolution images show near-complete cycle of DSB detection and repair. Findings have implications in enhancing cellular response to radiation and chemotherapy.
Tokyo Medical and Dental University (TMDU) researchers developed a class of molecules that mimic the structure of the CD4 proteins to divert HIV attachment to T helper cells. This work may lead to more effective treatments that are less likely to be affected by resistance mutations.
Researchers in Japan have found that the anti-diabetic drug metformin significantly prolongs the survival of mice in a model that simulates the pathology of non-diabetic chronic kidney disease (ND-CKD) by ameliorating pathological conditions like reduced kidney function, glomerular damage, inflammation and fibrosis. Metformin's mechanism is different from existing therapeutics which only treat symptoms, such as the blood pressure drug losartan, so researchers believe that a combination these medications at low dose will be highly beneficial.
Researchers at the Weizmann Institute of Science, together with colleagues from the Queen Mary University of London and the Hebrew University of Jerusalem, have revealed the mechanism of action of the master switch for hunger in the brain: the melanocortin receptor 4, or MC4 receptor for short. They have also clarified how this switch is activated by setmelanotide (Imcivree), a drug recently approved for the treatment of severe obesity caused by certain genetic changes.
What The Study Did: How prescribing of opioid analgesics and buprenorphine for opioid use disorder changed throughout the COVID-19 pandemic was examined in this study.